- The recommended dose of COSELA is 240 mg/m2 per dose. Administer as a 30-minute intravenous infusion completed within 4 hours before starting chemotherapy on each day chemotherapy is administered1
- Dosage forms and strengths: For injection: contains the equivalent of 300 mg of COSELA as a sterile, preservative-free, yellow lyophilized cake in a single-dose vial for reconstitution and further dilution
- The recommended dose of COSELA is 240 mg/m2 per dose. Administer as a 30-minute intravenous infusion completed within 4 hours before starting chemotherapy on each day chemotherapy is administered1
- Dosage forms and strengths: For injection: contains the equivalent of 300 mg of COSELA as a sterile, preservative-free, yellow lyophilized cake in a single-dose vial for reconstitution and further dilution
Monitor for signs and symptoms of injection-site reactions, including phlebitis and thrombophlebitis, during infusion. For severe or life-threatening reactions, stop infusion and permanently discontinue COSELA.
The interval between doses of COSELA on sequential days should not be greater than 28 hours
a
Upon completion of infusion of diluted COSELA solution, the infusion line/cannula MUST be flushed with at least 20 mL sterile 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP.
b
COSELA can be given within 4 hours before chemotherapy.
Recommended actions for adverse reactions
- If 0.9% Sodium Chloride Injection, USP is being used as a diluent/flush, consider changing to 5% Dextrose Injection, USP as appropriate for subsequent infusions1
- Note that COSELA is not a vesicant
c
Please see full Prescribing Information for additional dluent instructions.
d
Stop infusion in extremity and rotate site of infusion to site in alternative extremity.
e
Defined as: Grade 2=Moderate; minimal, local, or noninvasive intervention indicated; limited Activities of Daily Living. Grade 3=Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care Activities of Daily Living. Grade 4=Life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation).
f
Defined as: Grade 2=Symptomatic. Grade 3=Severe symptoms; limiting self-care Activities of Daily Living; oxygen indicated. Grade 4=Life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation).
g
Grade 3=Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care Activities of Daily Living. Grade 4=Life-threatening respiratory compromise; urgent intervention indicated.
Unexpected therapy interruption
The interval between doses of COSELA on sequential days should not be greater than 28 hours.1
Missed treatment session(s)1
- If the COSELA dose is missed, discontinue chemotherapy on the day the COSELA dose was missed. Consider resuming both COSELA and chemotherapy on the next scheduled day for chemotherapy
Discontinuation of treatment1
- If COSELA is discontinued, wait 96 hours from the last dose of COSELA before resumption of chemotherapy only
